EZH2 inhibition decreases neuroblastoma proliferation and in vivo tumor growth
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چکیده
منابع مشابه
In vitro and in vivo inhibition of neuroblastoma tumor cell growth by AKT inhibitor perifosine.
BACKGROUND Activated AKT is a marker of decreased event-free or overall survival in neuroblastoma (NB) patients. The aim of this study was to investigate the effect of perifosine, a nontoxic AKT inhibitor, as a single agent on NB cell growth in vitro and in vivo. METHODS Four human NB cell lines (AS, NGP, BE2, and KCNR) were treated with increasing concentrations of perifosine, and a quantita...
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2021
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0246244